By J.W. Gorrod, P. Jacob III
This publication offers for the 1st time a unmarried entire resource of knowledge at the analytical chemistry of nicotine and comparable alkaloids. The editors have introduced jointly scientists from academia and the tobacco to explain the cutting-edge of the chemistry and analytical tools for dimension of nicotine. either the scope and aspect of the e-book are notable. Chapters describe the historical past, pharmacology and toxicology of nicotine, the biosynthesis of nicotine and different alkaloids within the tobacco plant, the final chemistry of nicotine and the analytical methodologies which were used to degree nicotine and similar alkaloids in organic specimens, in tobacco and pharmaceutical items and in tobacco smoke. there's additionally a finished assessment of the chemistry and toxicology of nicotine-derived nitrosamines, an immense type of tobacco cancer causing agents.
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Extra resources for Analytical Determination of Nicotine and Related Compounds and their Metabolites
Some considerable homology was found between ORF8 and the iaaM gene of A. tumefaciens, which encodes a tryptophan monooxygenase active in oxidizing tryptophan to indole-3-acetamide, an intermediate in auxin synthesis. It was suggested that the gene product of ORF8 is indeed tryptophan monooxygenase. The authors proposed that these " . . genes play mainly a negative regulatory role in pathogenesis", and that they were significant in establishing infections of host plants. , related to what is so far known about how it affects nicotine biosynthesis.
Evidence has appeared that nicotine production is probably only part of a portfolio of defensive responses by the genus Nicotiana, comprising (at least) "... alkaloids, phenolics, proteinase inhibitors, PR (pathogenesis response) proteins, and sesquiterpenoid phytoalexins" (see ). An engaging account of these and related induced responses in other plants is given in 'Induced Responses to Herbivory' . Nicotiana sylvestris, a species native to South America, responds to leaf damage (insect larvae, mechanical cutting or puncturing) by accumulating, over about a week, as much as four-fold more shoot alkaloids than do comparable undamaged control plants .
Agric. Biol. , 1973: 37; 1755-1757. 79 Tiburcio AF, Kaur-Sawhney R, Ingersoll RB, Galston AW. Correlation between polyamines and pyrrolidine alkaloids in developing tobacco callus. , 1985: 78; 323-326. 80 Hashimoto T, Yamada Y. Regulation of tobacco alkaloid biosynthesis. ), Current Topics Plant Physiol 1995: 15; 130-144. 81 Baldwin IT. Chemical changes rapidly induced by folivory. ), Boca Raton: CRC Press, 1994: 5; 1-23. 82 Karban R, Baldwin IT. Induced Responses to Herbivory. Chicago: Univ. Chicago Press, 1997.