Alcohol Intoxication and Withdrawal I: Experimental Studies by H. Kalant (auth.), Milton M. Gross (eds.)

By H. Kalant (auth.), Milton M. Gross (eds.)

The contributions to this quantity essentially point out the momentum, caliber, liveliness and variety of the learn attempt being di­ rected towards deepening our realizing of tqe alcohol withdrawal syndrome. This sector of analysis has won expanding curiosity and a focus to the purpose the place it appeared moderate to commit a spe­ cial part to it on the thirtieth overseas Congress for Alcoholism and Drug Dependence in Amsterdam in September, 1972. Our aim was once to proportion our latest findings and stimulate others to hitch within the attempt. With few exceptions, the papers during this book current new information. It have been was hoping that the amount would seem via the tip of 1972. in spite of the fact that, the fervour of the various participants to increase their investigations made this aim date most unlikely. a number of of the papers weren't offered within the part yet have been offered in different places within the Congress. besides the fact that, due to their specific relevance to the subject they've been integrated with the beneficiant consent of the authors.

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IV. PRODUCTION OF AICOHOL DEPENDENCE IN THE RAT So far, only relatively mild signs of withdrawal illness have been reported in the rat (Gibbins, Kalant, LeBlanc and Clark, 1971; Cicero, Snider, Perez and Swanson, 1971). We have succeeded in producing a withdrawal state which includes, as its severest manifestation, tonic-clonic convulsions. This study has been reported in detail elsewhere (Wallgren, Kosunen and Ahtee, 1972). o. twice daily. The dose was adjusted to maintain maximal intoxication permitting adequate food intake, and a liquid diet was fed.

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1968. Enzyme expansion theory of drug tolerance and physical dependence, in The Addictive States (A. ), Res. Publ. Ass. Res. Nerv. Ment. Dis. 44: 265 - 267, Williams and Wilkins, Baltimore. Goldstein, A. , 1971. Alcohol dependence and opiate dependence: Lack of relationship in mice, Science, 172: 290 - 292. , 1972. Relationship of alcohol dose to intensity of withdrawal signs in mice, J. Pharmacol. Exp. Ther. 180: 203 - 215. B. , 1971. Alcohol dependence produced in mice by inhalation of ethanol: Grading the withdrawal reaction, Science, 172: 288 - 290.

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