By Shayne C. Gad
Acute toxicology trying out presents the 1st defensive position opposed to probably harmful chemical substances. This booklet is an entire and useful advisor to engaging in and examining all regulatory required and normal acute toxicity checks. It provides specific protocols for all the universal attempt designs and stories their improvement and ambitions. Acute Toxicology checking out, moment Edition will curiosity not just employees within the pharmaceutical undefined, but in addition researchers and scholars in toxicology and public health.
* Over a hundred tables summarizing and examining results
* entire assurance of all significant attempt designs and their barriers and advantages
* present prestige of other attempt designs and types
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Extra resources for Acute Toxicology Testing
15. 16. 39 with the other hand. The patch containing the test sample is then carefully placed into position onto the skin by raising the remaining three edges with tape dorsally until they are completely secured. 5 ml of physiological saline. If the test substance is a liquid, a patch is applied and secured to the appropriate skin site. 5 ml of test substance to the patch. If the test substance is a fabric, a 1 • 1-in. square sample is cut and placed on a patch. The test substance patch is placed on the appropriate skin site and secured.
This is done to clean the test site to facilitate accurate evaluation for skin irritation. Immediately after removal of the patches, each 1 • 1-in. square test or control site is outlined with an indelible marker by dotting each of the four corners. This procedure delineates the site for identification. C. Observations 1. Observations are made of the test and control skin sites 1 hr after removal of the patches (25 hr postinitiation of application). Ery- 40 Acute Toxicology Testing thema and edema are evaluated and scored on the basis of the designated values presented in Table 4.
1986a) and contain some internal controls (the positive and vehicle controls in the PDI) against large variabilities in results or the occurrence of either false positives or negatives, it is still essential to be aware of those factors which may systematically alter test results. These factors are summarized as follows: A. In general, any factor which increases absorption through the stratum corneum will also act to increase the severity of any intrinsic response. Unless these factors mirror potential exposure conditions, this may, in turn, adversely affect the relevance of test results.