A Guide to Practical Toxicology: Evaluation, Prediction, and by David Woolley, Visit Amazon's Adam Woolley Page, search

By David Woolley, Visit Amazon's Adam Woolley Page, search results, Learn about Author Central, Adam Woolley,

This functional, easy, and informative textual content surveys easy ideas of toxicology. it's a useful advisor to comparing toxicity and comparable facts, imminent toxicity checking out and interpretation, and realizing the ideas of risk prediction and possibility overview and management.

A consultant to sensible Toxicology:

  • examines the right way to review a number of teams of chemicals—pharmaceuticals, cosmetics, and agrochemicals
  • provides insights on toxicity choice, normality and naturality, prediction, and regulation

Two all-new chapters cover:

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Extra info for A Guide to Practical Toxicology: Evaluation, Prediction, and Risk, Second Edition

Sample text

Lead has effects Introduction to Toxicology: The Necessity of Measurement 25 Table 3 Factors in Target Organ Toxicity Factor Examples Blood supply Liver, kidney, and lung have greater blood supplies than adipose or muscle tissue Lung and paraquat toxicity Gastrointestinal mucosa, bone marrow, and toxicity of cytotoxic chemotherapies Hepatic change may be easily repaired while change in the CNS is not Concentration effects in the distal renal tubule Length and diameter of axons in the peripheral nervous system Liver and xenobiotic metabolism.

In order to get to the site of action in the kidney, the drug has to pass through the gastrointestinal tract and then the liver and the bloodstream. , furosemide) have been associated with effects on the hair cells in the inner ear leading to hearing impairment. Any program of work that seeks to investigate the effects of a novel compound intended for extensive, regulated use in man must, at some point, include experiments in animals that will examine these interrelationships. The down side is that, animal research is expensive and may not give a wholly reliable result when related to humans.

The kidney is a good example of an organ, in which particular parts may be affected while leaving the rest of the tissue apparently untouched. Damage to the glomerulus or the proximal convoluted tubule may not be reflected by visible change in other parts of the organ. However, the function of the kidney as a whole may be affected by influences such as blood pressure or hormonal diuresis, which may result in unwanted side effects in the rest of the organism. All toxic reactions have a biochemical basis, which may be more or less precise.

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