2012-2013 Nelson's Pediatric Antimicrobial Therapy, 19th by John S. Bradley MD, John D. Nelson MD Emeritus, Dr.

By John S. Bradley MD, John D. Nelson MD Emeritus, Dr. David W Kimberlin MD FAAP, Dr. John A.D. Leake MD MPH, Dr. Paul E Palumbo MD, Dr. Pablo J Sanchez MD, Dr. Jason Sauberan PharmD, Dr. William J Steinbach

This bestselling and ordinary source on pediatric antimicrobial remedy offers fast entry to trustworthy innovations for remedy of all infectious illnesses in children.

For each one affliction, the authors offer a statement to assist overall healthiness care companies choose the easiest of all antimicrobial offerings. The inquiring health care professional can instantly hyperlink to the proof for the advice within the e-book or cellular model. Drug descriptions disguise all antimicrobial brokers on hand at the present time and comprise entire information regarding dosing regimens.

In reaction to growing to be matters approximately overuse of antibiotics, the booklet contains guidance on whilst to not prescribe antimicrobials.

Key good points in nineteenth Edition!

- up to date information about the energy and the extent of proof for all therapy suggestions

- New bankruptcy on antibiotic treatment for overweight little ones

- New bankruptcy on antimicrobial prophylaxis and prevention of symptomatic an infection

- contains remedy of parasitic infections and tropical medication.

- up-to-date anti-infective drug directory, entire with formulations and dosages.

- Balanced details on protection, efficacy and tolerability with facts on bills and availability of substances

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Additional info for 2012-2013 Nelson's Pediatric Antimicrobial Therapy, 19th Edition

Sample text

Critical evaluations of duration of therapy have been carried out in very few infectious diseases. In general, a longer duration of therapy should be used (1) for tissues in which antibiotic concentrations may be relatively low (eg, abscess, CNS infection) and tissues in which repair following infection-mediated damage is slow (eg, bone), (2) when the organisms are less susceptible, (3) when a relapse of infection is unacceptable (eg, CNS infections), or (4) when the host is immunocompromised in some way.

Some experts would not treat but provide close serologic follow-up. 2012–2013 Nelson’s Pediatric Antimicrobial Therapy — 29 – Normal physical exam, Evaluation abnormal or not done completely: aqueous serum quantitative penicillin G 50,000 U/kg/dose q12h (day of life 1–7), q8h nontreponemal sero(>7 days) IV OR procaine penicillin G 50,000 U/kg IM logic titer ≤ maternal q24h for 10 days (AII) titer and maternal Evaluation normal: aqueous penicillin G 50,000 U/kg/dose treatment was q12h (day of life 1–7), q8h (>7 days) IV OR procaine (1) none, inadequate, penicillin G 50,000 U/kg IM q24h for 10 days; OR or undocumented; benzathine penicillin G 50,000 units/kg/dose IM (2) erythromycin, in a single dose azithromycin, or other non-penicillin regimen; or (3) <4 wk before delivery Condition Therapy (evidence grade) See Table 5B for Neonatal Dosages Comments – Normal physical exam, No treatment serum quantitative nontreponemal serologic titer ≤ maternal titer, and the mother’s treatment was adequate before pregnancy No evaluation required.

5 mg/kg/day IM (AIII) Other antipseudomonal antibiotics should also be effective: cefepime IV, meropenem IV or imipenem IV, pip/tazo – Bacterial furuncle of canal (S aureus, including CA-MRSA) Standard: oxacillin/nafcillin 150 mg/kg/day IV div q6h OR cefazolin 100 mg/kg/day IV div q8h (BIII) CA-MRSA: clindamycin 30 mg/kg/day IV div q8h or vancomycin 40 mg/kg/day IV q8h (BIII) I&D; antibiotics for cellulitis Oral therapy for mild disease, convalescent therapy: for MSSA: cephalexin; for CA-MRSA: clindamycin, TMP/SMX, OR linezolid (BIII) – Candida Fluconazole 5–10 mg/kg/day PO qd for 5–7 days (CIII) May occur following antibiotic therapy of bacterial external otitis; debride canal Otitis media, acute A note on AOM: The natural history of AOM in different age groups by specific pathogens has not been well defined; therefore, the actual contribution of antibiotic therapy on resolution of disease has also been poorly defined until 2 recent, amoxicillin/clavulanate vs placebo, blinded, prospective studies were published (Hoberman A et al 201169 and Tähtinen P et al 201170) although neither study requested tympanocentesis to define a pathogen.

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